As explained in the Editorial Charter, IIIS journal welcomes innovative, high-impact articles on emerging or deployed intelligent systems and technology with solid evaluation or evidence of success on a variety of topics. These topics include, but are not limited to:
- Intelligent agent systems
 
- Intelligent bioinformatics and biomedical systems
 
- Intelligent information and multimedia systems
 
- Intelligent robotic systems
 
- Intelligent tutoring and educational systems
 
- Knowledge engineering, modeling and capture systems
 
- Knowledge based software engineering
 
- Large-scale machine learning systems and technology
 
- Machine learning applications
 
- Online commerce, games, information search, and advertising systems
 
- Planning and scheduling systems
 
- Social intelligence systems
 
- Speech and language understanding and processing systems
 
- User behavior modeling and learning, intelligent user interfaces